Proteomics in the diagnosis and therapeutic management of human diseases: A review

Samuel Oluwaseun Alowoeshin; Togaju Babatunde Kuboye; Ifeanyi Raphael Ugwuanyi; Timothy Kwame Asem; Adeyemi Monday Mebinone; Shittu Ismail; Rejoice  Okafor; Oghenetejiri Ovwigho-ugbede; Benedict Onochie Ibe; Ejikeme Peter Igwe; Comfort Mary Afolabi

doi:10.5455/EJSRR.20250427010744

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Review Article
Online Published: 30 May 2025

Eu J Sci Res Rev. 2025; 3(1): 19-35

doi: 10.5455/EJSRR.20250427010744

Proteomics in the diagnosis and therapeutic management of human diseases: A review

Samuel Oluwaseun Alowoeshin, Togaju Babatunde Kuboye, Ifeanyi Raphael Ugwuanyi, Timothy Kwame Asem, Adeyemi Monday Mebinone, Shittu Ismail, Rejoice Okafor, Oghenetejiri Ovwigho-ugbede, Benedict Onochie Ibe, Ejikeme Peter Igwe, Comfort Mary Afolabi.

Abstract
Abstract

Proteomics is one of the major advances in understanding of human disease mechanisms, as well as, clinical applications with large scale study of proteins and functions. They include the traditional gel based technologies; the more advanced mass spectrometry and array based platforms, but the proteomic methods in this review are evolving from gel to mass spectrometry and then to array. Overall it is required to focus on the main branches such as structural, functional, clinical and metaproteomics related biomarker identification, disease diagnostic and therapeutic innovation. Proteomics is critically analyzed for its applications in diagnosing the neurodegenerative diseases (e.g., Alzheimer and Parkinsons), various cancers (e.g., ovarian and prostate), and cardiovascular conditions and the roles played by protein signatures, and post translatianal modifications, in disease pathology. also, therapeutical progress has been achieve through the enablement of drug target identification, mechanistic studies, and the combination of biomarker for precision medicine using the advances of proteomics. Linkage of proteomics to genomics, metabolomics, artificial intelligence and such inventions are current trends in which the resulting holistic disease model is envisioned. An area of standardization, lack of – or data integration; and another is translational validation — there are however ongoing innovations that will make proteomics more clinically useful. Future areas are the analytical sensitivity of the data, the discipline scope involved and use of a computational tool to better elucidate the proteomic data into a disease management and personalized healthcare strategies.

Key words: Keywords: therapeutics, cancer, biomarkers, neurodegenerative diseases.

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How to Cite this Article

Pubmed Style

Alowoeshin SO, Kuboye TB, Ugwuanyi IR, Asem TK, Mebinone AM, Ismail S, Okafor R, Ovwigho-ugbede O, Ibe BO, Igwe EP, Afolabi CM. Proteomics in the diagnosis and therapeutic management of human diseases: A review. Eu J Sci Res Rev. 2025; 3(1): 19-35. doi:10.5455/EJSRR.20250427010744

Web Style

Alowoeshin SO, Kuboye TB, Ugwuanyi IR, Asem TK, Mebinone AM, Ismail S, Okafor R, Ovwigho-ugbede O, Ibe BO, Igwe EP, Afolabi CM. Proteomics in the diagnosis and therapeutic management of human diseases: A review. https://www.wisdomgale.com/ejsrr/?mno=254735 [Access: June 25, 2025]. doi:10.5455/EJSRR.20250427010744

AMA (American Medical Association) Style

Alowoeshin SO, Kuboye TB, Ugwuanyi IR, Asem TK, Mebinone AM, Ismail S, Okafor R, Ovwigho-ugbede O, Ibe BO, Igwe EP, Afolabi CM. Proteomics in the diagnosis and therapeutic management of human diseases: A review. Eu J Sci Res Rev. 2025; 3(1): 19-35. doi:10.5455/EJSRR.20250427010744

Vancouver/ICMJE Style

Alowoeshin SO, Kuboye TB, Ugwuanyi IR, Asem TK, Mebinone AM, Ismail S, Okafor R, Ovwigho-ugbede O, Ibe BO, Igwe EP, Afolabi CM. Proteomics in the diagnosis and therapeutic management of human diseases: A review. Eu J Sci Res Rev. (2025), [cited June 25, 2025]; 3(1): 19-35. doi:10.5455/EJSRR.20250427010744

Harvard Style

Alowoeshin, S. O., Kuboye, . T. B., Ugwuanyi, . I. R., Asem, . T. K., Mebinone, . A. M., Ismail, . S., Okafor, . R., Ovwigho-ugbede, . O., Ibe, . B. O., Igwe, . E. P. & Afolabi, . C. M. (2025) Proteomics in the diagnosis and therapeutic management of human diseases: A review. Eu J Sci Res Rev, 3 (1), 19-35. doi:10.5455/EJSRR.20250427010744

Turabian Style

Alowoeshin, Samuel Oluwaseun, Togaju Babatunde Kuboye, Ifeanyi Raphael Ugwuanyi, Timothy Kwame Asem, Adeyemi Monday Mebinone, Shittu Ismail, Rejoice Okafor, Oghenetejiri Ovwigho-ugbede, Benedict Onochie Ibe, Ejikeme Peter Igwe, and Comfort Mary Afolabi. 2025. Proteomics in the diagnosis and therapeutic management of human diseases: A review. European Journal of Scientific Research and Reviews, 3 (1), 19-35. doi:10.5455/EJSRR.20250427010744

Chicago Style

Alowoeshin, Samuel Oluwaseun, Togaju Babatunde Kuboye, Ifeanyi Raphael Ugwuanyi, Timothy Kwame Asem, Adeyemi Monday Mebinone, Shittu Ismail, Rejoice Okafor, Oghenetejiri Ovwigho-ugbede, Benedict Onochie Ibe, Ejikeme Peter Igwe, and Comfort Mary Afolabi. "Proteomics in the diagnosis and therapeutic management of human diseases: A review." European Journal of Scientific Research and Reviews 3 (2025), 19-35. doi:10.5455/EJSRR.20250427010744

MLA (The Modern Language Association) Style

Alowoeshin, Samuel Oluwaseun, Togaju Babatunde Kuboye, Ifeanyi Raphael Ugwuanyi, Timothy Kwame Asem, Adeyemi Monday Mebinone, Shittu Ismail, Rejoice Okafor, Oghenetejiri Ovwigho-ugbede, Benedict Onochie Ibe, Ejikeme Peter Igwe, and Comfort Mary Afolabi. "Proteomics in the diagnosis and therapeutic management of human diseases: A review." European Journal of Scientific Research and Reviews 3.1 (2025), 19-35. Print. doi:10.5455/EJSRR.20250427010744

APA (American Psychological Association) Style

Alowoeshin, S. O., Kuboye, . T. B., Ugwuanyi, . I. R., Asem, . T. K., Mebinone, . A. M., Ismail, . S., Okafor, . R., Ovwigho-ugbede, . O., Ibe, . B. O., Igwe, . E. P. & Afolabi, . C. M. (2025) Proteomics in the diagnosis and therapeutic management of human diseases: A review. European Journal of Scientific Research and Reviews, 3 (1), 19-35. doi:10.5455/EJSRR.20250427010744

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