Effect of Giving Supplements Rich in Enzyme CYP2E1 on Platelet Concentration in Blood: A Study on Home Shoes Industry Workers of Osowilangun Tambak

Fadhil Muhammad Razzan; abdul Rohim  Tualeka; azeez Olawale Ojelabi; denny  Ardyanto; gurendro  Putro; aceng  Ruyani; dina Keumala Sari; dimas Rahadian Aji Muhammad; dewi  Rokhmah; nur  Mukarromah; tri Niswati Utami; rizky Rahadian Wicaksono; rachmy Rosyida Rois; ellyza Setya Maryiantari; susmiati Susmiati; aris  Santjaka; suardi  Zurimi; hairudin  Rasako; mintje Maria Nendissa; eko  Nurmianto; pipid Ari Wibowo; ikhram  Hardi; rizaldy Fathur Rachman; umi  Salmah; roy Januardi Irawan; sunardi Sunardi; juliana  Jalaludin

Abstract
Introduction: The hazardous chemical benzene, which is present in glue and can damage bone marrow and lower blood platelet concentration, is frequently exposed to during the shoe-making process. The CYP2E1 enzyme is essential for the metabolism of benzene, which helps the body eliminate it and lessens its harmful effects. The purpose of this study is to examine how supplements containing CYP2E1 enzymes affect the platelet concentration of shoe workers in Tambak Osowilangun Village's home industry sector. Methods: A pre-experimental study was conducted using a one-group pretest-posttest design. There were twenty-seven (27) workers in the sample. Interviews, body mass index (BMI) calculations, and blood platelet concentration tests were used to gather data before and after CYP2E1 enzyme supplementation. SPSS was used for statistical analysis in order to evaluate variations in platelet concentration and determine the factors affecting these variations. Results: Following the five-day supplementation period, the platelet concentration increased by 100%, according to the results. Employees who lived far from the production site, were older males with higher BMIs, non-smoker, had more than 15 years of work experience, and worked more than 8 hours a day benefited the most. Conclusion: In conclusion, giving shoe workers supplements high in the CYP2E1 enzyme had a beneficial impact and raised their platelet counts considerably. The consumption of foods high in CYP2E1 should be encouraged, regular physical activity should be encouraged, and working conditions should be improved. Control groups and longer treatment durations could be added to future studies.

Key words: benzene, cyp2e1, platelet, shoe industry, supplement