E-ISSN 3041-4814
 

Original Article
Online Published: 18 May 2025
 


Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats

Umar Abdullahi Maina, Emmanuel O Adawaren, Umaru Bukar, Saidu Ibrahim Ngulde, Lawan Kaumi, Yagana Bukar Majama, Sabo I Salihu, Ayuba David Telta.


Abstract
Aim/Background: The study was conducted to evaluate histopathological changes in the kidney, liver and intestines following sub-acute oral administration of Hibiscus sabdariffa aqueous extract in albino rat.
Methods: A controlled experimental design with a total number of 20 rats were divided into four groups (A, B, C, and D) of n= 5 each and administered varying doses (dosage) of the extract for 28 days. Tissue samples from the kidney, liver, and intestines were collected and subjected to histopathological studies. The entire research work was carried out between Septembers to December 2024.
Results: The results revealed dose-dependent adverse effect on the tissue microscopy of the organs. Renal lesions observed include degeneration, necrosis, and glomerular atrophy. The liver exhibited necrosis, hepatocellular degeneration, and dilation of the central vein with hepatic vacuolation. While the intestines showed villus atrophy and necrosis with dose dependent severity.
Conclusion: Prolonged administration/use of H. Sabdariffa aqueous extract especially in higher concentration may pose potential risk to organ health despites its acknowledged health benefit. This study recommends further investigation into its safety profile particularly for prolonged and high-dose use to consolidate on this findings consequently ensure its therapeutic safety.

Key words: Hibiscus sabdariffa, Liver, Kidney, Intestine, Sub-acute, toxicity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Umar Abdullahi Maina
Articles by Emmanuel O Adawaren
Articles by Umaru Bukar
Articles by Saidu Ibrahim Ngulde
Articles by Lawan Kaumi
Articles by Yagana Bukar Majama
Articles by Sabo I Salihu
Articles by Ayuba David Telta
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Maina UA, Adawaren EO, Bukar U, Ngulde SI, Kaumi L, Majama YB, Salihu SI, Telta AD. Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats. J Exp Lab Med. 2025; 2(2): 77-83. doi:10.5455/JELM.20250325124456


Web Style

Maina UA, Adawaren EO, Bukar U, Ngulde SI, Kaumi L, Majama YB, Salihu SI, Telta AD. Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats. https://www.wisdomgale.com/jelm/?mno=302657879 [Access: May 25, 2025]. doi:10.5455/JELM.20250325124456


AMA (American Medical Association) Style

Maina UA, Adawaren EO, Bukar U, Ngulde SI, Kaumi L, Majama YB, Salihu SI, Telta AD. Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats. J Exp Lab Med. 2025; 2(2): 77-83. doi:10.5455/JELM.20250325124456



Vancouver/ICMJE Style

Maina UA, Adawaren EO, Bukar U, Ngulde SI, Kaumi L, Majama YB, Salihu SI, Telta AD. Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats. J Exp Lab Med. (2025), [cited May 25, 2025]; 2(2): 77-83. doi:10.5455/JELM.20250325124456



Harvard Style

Maina, U. A., Adawaren, . E. O., Bukar, . U., Ngulde, . S. I., Kaumi, . L., Majama, . Y. B., Salihu, . S. I. & Telta, . A. D. (2025) Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats. J Exp Lab Med, 2 (2), 77-83. doi:10.5455/JELM.20250325124456



Turabian Style

Maina, Umar Abdullahi, Emmanuel O Adawaren, Umaru Bukar, Saidu Ibrahim Ngulde, Lawan Kaumi, Yagana Bukar Majama, Sabo I Salihu, and Ayuba David Telta. 2025. Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats. Journal of Experimental and Laboratory Medicine, 2 (2), 77-83. doi:10.5455/JELM.20250325124456



Chicago Style

Maina, Umar Abdullahi, Emmanuel O Adawaren, Umaru Bukar, Saidu Ibrahim Ngulde, Lawan Kaumi, Yagana Bukar Majama, Sabo I Salihu, and Ayuba David Telta. "Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats." Journal of Experimental and Laboratory Medicine 2 (2025), 77-83. doi:10.5455/JELM.20250325124456



MLA (The Modern Language Association) Style

Maina, Umar Abdullahi, Emmanuel O Adawaren, Umaru Bukar, Saidu Ibrahim Ngulde, Lawan Kaumi, Yagana Bukar Majama, Sabo I Salihu, and Ayuba David Telta. "Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats." Journal of Experimental and Laboratory Medicine 2.2 (2025), 77-83. Print. doi:10.5455/JELM.20250325124456



APA (American Psychological Association) Style

Maina, U. A., Adawaren, . E. O., Bukar, . U., Ngulde, . S. I., Kaumi, . L., Majama, . Y. B., Salihu, . S. I. & Telta, . A. D. (2025) Sub-acute Toxicity Assessment of Orally Administered Aqueous Extract of Habiscus Sabdariffa on the Liver, Kidney and Intestine of Wistar Rats. Journal of Experimental and Laboratory Medicine, 2 (2), 77-83. doi:10.5455/JELM.20250325124456