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Original Article

Online Publishing Date:
23 / 05 / 2024



Prognostic value of thrombomodulin molecule in COVID-19 patients

Kezban Ozmen Süner, Havva Kocayiğit, Kubilay Işsever, Betül Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, Oğuz Karabay.


Abstract
Background:The purpose of this study is to evaluate serum thrombomodulin(TM) levels in coronavirus disease 2019(COVID-19) patients and to investigate whether TM predicts the severity of COVID-19 and coagulopathy .
Materials and methods:This study was conducted on 87 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia.The patients were divided into two groups as intensive care unit(ICU) patients and non-ICU patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the TM and other laboratory parameters of the patients.
Results:Of 87 patients with COVID-19, 40(45%) were ICU patients and 47(55%) were non-ICU patients. 40(45%) of the patients were men.TM median value(IQR) was 1.22ng/mL (0.9–2.2) in all patients, 1.2ng/mL(0.8–2.3) in non-ICU patients and 1.3ng/mL (1.0–2.21) in ICU patients (p=0.485).As a receiver operating characteristic curve analysis the cut-off value of TM for predicting mortality in patients was 1.27 with 60% sensitivity and 54% specificity (AUC: 0.550, 95% CI: 0.384-0.716, P= 0.602).Also, we found significant cut-off values with respect to troponin, D-dimer, CRP, fibrinogen, procalcitonin, LDH, and ferritin(p< 0.05).
Conclusion:This study found no significant difference between TM levels in ICU versus non-ICU groups.We further showed that there is no relation between TM levels and mortality.

Key words: prognostic value, thrombomodulin molecule, COVID-19, endotheliitis


 
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How to Cite this Article
Pubmed Style

KOS, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, SY, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis. 2024; 1(1): 30-36. doi:10.5455/EJMID.20240424010154

Web Style

KOS, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, SY, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. https://www.wisdomgale.com/ejmid/?mno=198961 [Access: June 03, 2024]. doi:10.5455/EJMID.20240424010154

AMA (American Medical Association) Style

KOS, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, SY, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis. 2024; 1(1): 30-36. doi:10.5455/EJMID.20240424010154


Vancouver/ICMJE Style

KOS, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, SY, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis. (2024), [cited June 03, 2024]; 1(1): 30-36. doi:10.5455/EJMID.20240424010154


Harvard Style

, K. O. S., Kocayiğit, . H., Işsever, . K., Tuncer, . B., Cokluk, . E., Toptan, . H., , . S. Y. & Karabay, . O. (2024) Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis, 1 (1), 30-36. doi:10.5455/EJMID.20240424010154


Turabian Style

, Kezban Ozmen Suner, Havva Kocayiğit, Kubilay Işsever, Betul Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, and Oğuz Karabay. 2024. Prognostic value of thrombomodulin molecule in COVID-19 patients. European Journal of Microbiology and Infectious Diseases, 1 (1), 30-36. doi:10.5455/EJMID.20240424010154


Chicago Style

, Kezban Ozmen Suner, Havva Kocayiğit, Kubilay Işsever, Betul Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, and Oğuz Karabay. "Prognostic value of thrombomodulin molecule in COVID-19 patients." European Journal of Microbiology and Infectious Diseases 1 (2024), 30-36. doi:10.5455/EJMID.20240424010154


MLA (The Modern Language Association) Style

, Kezban Ozmen Suner, Havva Kocayiğit, Kubilay Işsever, Betul Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, and Oğuz Karabay. "Prognostic value of thrombomodulin molecule in COVID-19 patients." European Journal of Microbiology and Infectious Diseases 1.1 (2024), 30-36. Print. doi:10.5455/EJMID.20240424010154


APA (American Psychological Association) Style

, K. O. S., Kocayiğit, . H., Işsever, . K., Tuncer, . B., Cokluk, . E., Toptan, . H., , . S. Y. & Karabay, . O. (2024) Prognostic value of thrombomodulin molecule in COVID-19 patients. European Journal of Microbiology and Infectious Diseases, 1 (1), 30-36. doi:10.5455/EJMID.20240424010154


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