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2024, Vol: 11, Issue: 1
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Case Report

Online Publishing Date:
21 / 07 / 2023



DOTOTATE: Positive is not always NET

Brandon J Xavier, Christine Marie-Gilligan Schammel, David P Schammel, Steven D Trocha, Eric Farnsworth, Aron Michael Devane.


Abstract
Introduction: Neuroendocrine tumors (NET) are increasing in incidence, and the use of 68Ga-DOTOTATE PET/CT to specifically identify NET has aided with early diagnosis, with 83%-100% sensitivity.
Case: Here, we present a case in which a suspected small bowel obstruction by CT was 68Ga-DOTOTATE PET/CT avid in both the mass and adjacent nodes, suggestive of NET. However, the mass was not consistent with NET during surgical resection and the intra-operative frozen section revealed heterotopic pancreatic tissue and necrotic fat. Surgical resection would have been extensive and morbid; given the lack of a malignant diagnosis, it was aborted.
Discussion: A comprehensive literature review demonstrated few false positive lesions identified by 68Ga-DOTOTATE; most frequently lymph nodes, pancreas, and prostate. Our case is the only reported false positive in a necrotic lesion. These cases highlight the importance of evaluating 68Ga-DOTOTATE PET/CT imaging for NET in the global context and presentation of the patient.

Key words: Neuroendocrine tumor, NET, DOTOTATE, 68Ga-DOTOTATE, false positive


 
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How to Cite this Article
Pubmed Style

Xavier BJ, Schammel CM, Schammel DP, Trocha SD, Farnsworth E, Devane AM, . DOTOTATE: Positive is not always NET. A J Diagn Imaging. 2023; 9(4): 47-51. doi:10.5455/ajdi.20230314010926

Web Style

Xavier BJ, Schammel CM, Schammel DP, Trocha SD, Farnsworth E, Devane AM, . DOTOTATE: Positive is not always NET. https://www.scopub.com/ajdi/?mno=146350 [Access: February 20, 2024]. doi:10.5455/ajdi.20230314010926

AMA (American Medical Association) Style

Xavier BJ, Schammel CM, Schammel DP, Trocha SD, Farnsworth E, Devane AM, . DOTOTATE: Positive is not always NET. A J Diagn Imaging. 2023; 9(4): 47-51. doi:10.5455/ajdi.20230314010926


Vancouver/ICMJE Style

Xavier BJ, Schammel CM, Schammel DP, Trocha SD, Farnsworth E, Devane AM, . DOTOTATE: Positive is not always NET. A J Diagn Imaging. (2023), [cited February 20, 2024]; 9(4): 47-51. doi:10.5455/ajdi.20230314010926


Harvard Style

Xavier, B. J., Schammel, C. M., Schammel, D. P., Trocha, S. D., Farnsworth, E., Devane, A. M. & (2023) DOTOTATE: Positive is not always NET. A J Diagn Imaging, 9 (4), 47-51. doi:10.5455/ajdi.20230314010926


Turabian Style

Xavier, Brandon J, Christine Marie-Gilligan Schammel, David P Schammel, Steven D Trocha, Eric Farnsworth, Aron Michael Devane, and . 2023. DOTOTATE: Positive is not always NET. American Journal of Diagnostic Imaging , 9 (4), 47-51. doi:10.5455/ajdi.20230314010926


Chicago Style

Xavier, Brandon J, Christine Marie-Gilligan Schammel, David P Schammel, Steven D Trocha, Eric Farnsworth, Aron Michael Devane, and . "DOTOTATE: Positive is not always NET." American Journal of Diagnostic Imaging 9 (2023), 47-51. doi:10.5455/ajdi.20230314010926


MLA (The Modern Language Association) Style

Xavier, Brandon J, Christine Marie-Gilligan Schammel, David P Schammel, Steven D Trocha, Eric Farnsworth, Aron Michael Devane, and . "DOTOTATE: Positive is not always NET." American Journal of Diagnostic Imaging 9.4 (2023), 47-51. Print. doi:10.5455/ajdi.20230314010926


APA (American Psychological Association) Style

Xavier, B. J., Schammel, C. M., Schammel, D. P., Trocha, S. D., Farnsworth, E., Devane, A. M. & (2023) DOTOTATE: Positive is not always NET. American Journal of Diagnostic Imaging , 9 (4), 47-51. doi:10.5455/ajdi.20230314010926


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