E-ISSN 2577-2058
 

Case Report
Online Published: 15 Mar 2025
 


Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia

Kaoutar Fahmaoui, Ghizlane Zouhir, Mohammed Amine Hammouche, Mohamed Réda Bentouhami, Youness Hidan, Adil Mchachi, Laila Benhmidoune, Rayad Rachid.


Abstract
Purpose. To describe a unique case of posterior ischemic optic neuropathy (PION) in a 36-year-old man with sickle cell disease (SCD) and Moyamoya syndrome (MMS), highlighting the rare and complex interaction of these conditions and their implications in ocular ischemic events.
Case Report. A North African male with homozygous SCD presented with sudden, painless diminution of vision in his left eye, two months before consulting in our department. On examination, his visual acuity was preserved in the right eye but limited to counting fingers at one meter in the left eye. A significant left relative afferent pupillary defect was noted. Funduscopic examination and Fluorescein angiography showed signs of proliferative sickle cell retinopathy, with optic disc atrophy in the left eye. Computed tomography angiography and magnetic resonance angiography of the brain confirmed MMS with stenosis of the internal carotid artery and Moyamoya vessel formation, as well as optic nerve atrophy. No recovery in visual acuity was observed one year later.
Conclusion. This case is notable for the unusual coexistence of SCD, MMS, and PION in the same patient. It also highlights the complexity of managing coexisting SCD and MMS, as both conditions amplify the risk of cerebral and ocular ischemic events, leading to irreversible vision loss. Multidisciplinary care is essential to monitor and address the diverse manifestations of these overlapping conditions and prevent severe outcomes.

Key words: Posterior ischemic optic neuropathy; Sickle cell disease; Moyamoya syndrome; Computed tomography angiography; Magnetic resonance angiography


 
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How to Cite this Article
Pubmed Style

Fahmaoui K, Zouhir G, Hammouche MA, Bentouhami MR, Hidan Y, Mchachi A, Benhmidoune L, Rachid R. Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia. A J Diagn Imaging. 2025; 11(2): 19-25. doi:10.5455/ajdi.20250128090244


Web Style

Fahmaoui K, Zouhir G, Hammouche MA, Bentouhami MR, Hidan Y, Mchachi A, Benhmidoune L, Rachid R. Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia. https://www.wisdomgale.com/ajdi/?mno=240156 [Access: March 20, 2025]. doi:10.5455/ajdi.20250128090244


AMA (American Medical Association) Style

Fahmaoui K, Zouhir G, Hammouche MA, Bentouhami MR, Hidan Y, Mchachi A, Benhmidoune L, Rachid R. Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia. A J Diagn Imaging. 2025; 11(2): 19-25. doi:10.5455/ajdi.20250128090244



Vancouver/ICMJE Style

Fahmaoui K, Zouhir G, Hammouche MA, Bentouhami MR, Hidan Y, Mchachi A, Benhmidoune L, Rachid R. Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia. A J Diagn Imaging. (2025), [cited March 20, 2025]; 11(2): 19-25. doi:10.5455/ajdi.20250128090244



Harvard Style

Fahmaoui, K., Zouhir, . G., Hammouche, . M. A., Bentouhami, . M. R., Hidan, . Y., Mchachi, . A., Benhmidoune, . L. & Rachid, . R. (2025) Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia. A J Diagn Imaging, 11 (2), 19-25. doi:10.5455/ajdi.20250128090244



Turabian Style

Fahmaoui, Kaoutar, Ghizlane Zouhir, Mohammed Amine Hammouche, Mohamed Réda Bentouhami, Youness Hidan, Adil Mchachi, Laila Benhmidoune, and Rayad Rachid. 2025. Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia. American Journal of Diagnostic Imaging , 11 (2), 19-25. doi:10.5455/ajdi.20250128090244



Chicago Style

Fahmaoui, Kaoutar, Ghizlane Zouhir, Mohammed Amine Hammouche, Mohamed Réda Bentouhami, Youness Hidan, Adil Mchachi, Laila Benhmidoune, and Rayad Rachid. "Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia." American Journal of Diagnostic Imaging 11 (2025), 19-25. doi:10.5455/ajdi.20250128090244



MLA (The Modern Language Association) Style

Fahmaoui, Kaoutar, Ghizlane Zouhir, Mohammed Amine Hammouche, Mohamed Réda Bentouhami, Youness Hidan, Adil Mchachi, Laila Benhmidoune, and Rayad Rachid. "Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia." American Journal of Diagnostic Imaging 11.2 (2025), 19-25. Print. doi:10.5455/ajdi.20250128090244



APA (American Psychological Association) Style

Fahmaoui, K., Zouhir, . G., Hammouche, . M. A., Bentouhami, . M. R., Hidan, . Y., Mchachi, . A., Benhmidoune, . L. & Rachid, . R. (2025) Posterior ischemic optic neuropathy as a complication of Moyamoya syndrome in a 36-year-old male with sickle cell anemia. American Journal of Diagnostic Imaging , 11 (2), 19-25. doi:10.5455/ajdi.20250128090244