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2025, Vol: 2, Issue: 1
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Original Article
Online Published: 06 Feb 2025
 


Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation

Rissa Ismawati, Chodijah Chodijah, Titiek Sumarawati, Agung Putra, Prasetyowati Subchan.


Abstract
Background: UVB exposure can induce melanin synthesis by increasing MDA levels and suppressing interleukin-10 (IL-10) expression. Metabolite compounds in Stink bean extract may inhibit oxidative stress caused by UVB exposure. This study aimed to determine the effect of Stink bean extract gel on MDA and IL-10 levels in rat skin tissue exposed to high-intensity UVB.Methods: This study used a posttest-only control group design with a completely randomized method. The sample consisted of 24 rats exposed to 302 nm UVB radiation at 390 mJ/cm2/day, 3 times a week for 2 weeks. The study included four groups: healthy control (K1), negative control (K2), treatment 1 (K3) with 10% Stink bean extract gel, and treatment 2 (K4) with 20% Stink bean extract gel. MDA and IL-10 levels were analyzed using ELISA assay. Results: ELISA analysis showed a significant decrease in mean MDA levels in K4 (0.61±0.15) and K3 (0.71±0.11) compared to the negative control (1.65±0.30) with p<0.05. Analysis of IL-10 levels also showed a significant increase in mean IL-10 levels in K3 (189.00±11.41) and K4 (252.49±4.37) compared to the negative control (96.42±6.16) with p<0.05. Conclusion: Stink bean extract gel administration can suppress MDA levels and increase IL-10 levels in UVB-exposed photoaging rat models.

Key words: UVB exposure, Stink bean extract, MDA, IL-10


 
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How to Cite this Article
Pubmed Style

Ismawati R, Chodijah C, Sumarawati T, Putra A, Subchan P. Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation. J Exp Lab Med. 2025; 2(1): 18-26. doi:10.5455/JELM.20241029034553

Web Style

Ismawati R, Chodijah C, Sumarawati T, Putra A, Subchan P. Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation. https://www.wisdomgale.com/jelm/?mno=226530 [Access: February 11, 2025]. doi:10.5455/JELM.20241029034553

AMA (American Medical Association) Style

Ismawati R, Chodijah C, Sumarawati T, Putra A, Subchan P. Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation. J Exp Lab Med. 2025; 2(1): 18-26. doi:10.5455/JELM.20241029034553


Vancouver/ICMJE Style

Ismawati R, Chodijah C, Sumarawati T, Putra A, Subchan P. Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation. J Exp Lab Med. (2025), [cited February 11, 2025]; 2(1): 18-26. doi:10.5455/JELM.20241029034553


Harvard Style

Ismawati, R., Chodijah, . C., Sumarawati, . T., Putra, . A. & Subchan, . P. (2025) Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation. J Exp Lab Med, 2 (1), 18-26. doi:10.5455/JELM.20241029034553


Turabian Style

Ismawati, Rissa, Chodijah Chodijah, Titiek Sumarawati, Agung Putra, and Prasetyowati Subchan. 2025. Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation. Journal of Experimental and Laboratory Medicine, 2 (1), 18-26. doi:10.5455/JELM.20241029034553


Chicago Style

Ismawati, Rissa, Chodijah Chodijah, Titiek Sumarawati, Agung Putra, and Prasetyowati Subchan. "Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation." Journal of Experimental and Laboratory Medicine 2 (2025), 18-26. doi:10.5455/JELM.20241029034553


MLA (The Modern Language Association) Style

Ismawati, Rissa, Chodijah Chodijah, Titiek Sumarawati, Agung Putra, and Prasetyowati Subchan. "Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation." Journal of Experimental and Laboratory Medicine 2.1 (2025), 18-26. Print. doi:10.5455/JELM.20241029034553


APA (American Psychological Association) Style

Ismawati, R., Chodijah, . C., Sumarawati, . T., Putra, . A. & Subchan, . P. (2025) Effect of Stink Bean Extract Gel on MDA and IL-10 Levels in UVB-Exposed Rat Skin Tissue: A Preclinical Investigation. Journal of Experimental and Laboratory Medicine, 2 (1), 18-26. doi:10.5455/JELM.20241029034553


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