E-ISSN 3041-4156
 
2025, Vol: 2, Issue: 2
2 / 2Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Original Article
Online Published: 31 Mar 2025
 


Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches

Mohammad Nadeem Khan, Mahek Bhandari, Sanjay Vyas, Shushil Upadhayay, Praveen Chandra Dubey.


Abstract
Background: - Chandipura virus (CHPV), a member of the Rhabdoviridae family, is a significant cause of viral encephalitis in India, with limited treatment options. This highlights the urgent need for novel antiviral drug discovery strategies.
Methods: - This study explores the antiviral potential of Garuga pinnata phytochemicals against CHPV using in-silico approaches. Molecular docking was performed against three viral proteins: Vesicular stomatitis virus (VSV) G-protein, VSV M-protein, and the Chandipura N-protein complex. Seven phytochemicals, including 21-Hydroxydammar-24-en-3-one and 6-Hydroxygaruanin-V, were screened for their binding affinities. ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling was conducted to evaluate their pharmacokinetic properties and safety profiles.
Results:- 21-Hydroxydammar-24-en-3-one exhibited the highest binding affinity with VSV M-protein (-16.2 kcal/mol) and the Chandipura N-protein complex (-15.8 kcal/mol). 6-Hydroxygaruanin-V showed significant binding with VSV G-protein, with binding energies ranging from -13.4 to -16.1 kcal/mol. ADMET analysis revealed favorable drug-likeness for both compounds, with positive pharmacokinetic properties and minimal risks of mutagenicity and carcinogenicity. However, 21-Hydroxydammar-24-en-3-one showed moderate risks in some safety assays.
Conclusion: - The strong binding affinities and favorable ADMET profiles of Garuga pinnata phytochemicals suggest their potential to disrupt CHPV viral assembly, making them promising candidates for antiviral therapy. Future studies should focus on in vivo validation, detailed mechanistic analyses, and optimization of these phytochemicals to enhance their therapeutic efficacy.

Key words: Encephalitis, Phytochemical Ligands, In-Silico Analysis, Molecular Docking, Viral Proteins, ADMET Analysis Receptor Binding, Drug Discovery


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mohammad Nadeem Khan
Articles by Mahek Bhandari
Articles by Sanjay Vyas
Articles by Shushil Upadhayay
Articles by Praveen Chandra Dubey
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Khan MN, Bhandari M, Vyas S, Upadhayay S, Dubey PC. Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches. J Pharmacol Pharm Res. 2025; 2(2): 42-51. doi:10.5455/JPPR.20250306051038

Web Style

Khan MN, Bhandari M, Vyas S, Upadhayay S, Dubey PC. Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches. https://www.wisdomgale.com/jppr/?mno=302657867 [Access: April 21, 2025]. doi:10.5455/JPPR.20250306051038

AMA (American Medical Association) Style

Khan MN, Bhandari M, Vyas S, Upadhayay S, Dubey PC. Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches. J Pharmacol Pharm Res. 2025; 2(2): 42-51. doi:10.5455/JPPR.20250306051038


Vancouver/ICMJE Style

Khan MN, Bhandari M, Vyas S, Upadhayay S, Dubey PC. Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches. J Pharmacol Pharm Res. (2025), [cited April 21, 2025]; 2(2): 42-51. doi:10.5455/JPPR.20250306051038


Harvard Style

Khan, M. N., Bhandari, . M., Vyas, . S., Upadhayay, . S. & Dubey, . P. C. (2025) Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches. J Pharmacol Pharm Res, 2 (2), 42-51. doi:10.5455/JPPR.20250306051038


Turabian Style

Khan, Mohammad Nadeem, Mahek Bhandari, Sanjay Vyas, Shushil Upadhayay, and Praveen Chandra Dubey. 2025. Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches. Journal of Pharmacological and Pharmaceutical Research, 2 (2), 42-51. doi:10.5455/JPPR.20250306051038


Chicago Style

Khan, Mohammad Nadeem, Mahek Bhandari, Sanjay Vyas, Shushil Upadhayay, and Praveen Chandra Dubey. "Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches." Journal of Pharmacological and Pharmaceutical Research 2 (2025), 42-51. doi:10.5455/JPPR.20250306051038


MLA (The Modern Language Association) Style

Khan, Mohammad Nadeem, Mahek Bhandari, Sanjay Vyas, Shushil Upadhayay, and Praveen Chandra Dubey. "Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches." Journal of Pharmacological and Pharmaceutical Research 2.2 (2025), 42-51. Print. doi:10.5455/JPPR.20250306051038


APA (American Psychological Association) Style

Khan, M. N., Bhandari, . M., Vyas, . S., Upadhayay, . S. & Dubey, . P. C. (2025) Antiviral Potential of Garuga pinnata Roxb. Against Chandipura Virus: An Integration of Traditional Knowledge and In-Silico Approaches. Journal of Pharmacological and Pharmaceutical Research, 2 (2), 42-51. doi:10.5455/JPPR.20250306051038


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesTerms of UseLicense InformationCopyright Information

About Journal of Pharmacological and Pharmaceutical Research

Journal of Pharmacological and Pharmaceutical Research is an international, peer-reviewed, open access journal, providing a platform for advances in basic ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

Your comments are very important to us

We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below.
 

Emails:

info@wisdomgale.com
editorinchief@ejmanager.com

Office Address:
WisdomGale Publishing
14 Rue de Grand-Bigard,
1082 Brussels
Belgium
 
We will respond within 48 to 72 hours.
 
Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.