Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series

Aya Kawssan; Abbas Al Bazzal; Aktham Abdelhadi; Hiba Hamdar

doi:10.5455/JMRR.20251219010830

J Med Res Rev. 2026; 5(3): 116-124

doi: 10.5455/JMRR.20251219010830

Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series

Aya Kawssan, Abbas Al Bazzal, Aktham Abdelhadi, Hiba Hamdar.

Abstract
Aim/Background: Diagnostic uncertainty persists as a major driver of preventable patient harm in clinical practice. This feasibility study examined whether a structured data-submission protocol — the Rapid Dx Analyzer and Clinical Decision Tool (R-DA) — could improve the reliability of a commercial large language model (LLM) in generating differential diagnoses for complex clinical presentations. Methods: A single-user, retrospective case series was conducted. Twenty non-consecutive clinical cases were selected from an institutional database using pre-defined complexity criteria (involvement of two or
more organ systems, three or more differential diagnoses, ambiguous or conflicting data, or time-todiagnosis exceeding 48 hours). For each case, a structured prompt was submitted to Gemini 3.0 Pro via its web interface. The primary outcome was diagnostic concordance — defined as the model's top-ranked output matching the confirmed clinical diagnosis (established by biopsy, surgical findings, or definitive clinical course). The clinician providing input was not blinded to the final diagnosis.
Results: Concordance between the R-DA-generated output and the confirmed diagnosis was observed in all 20 cases (100%; 95% CI [Clopper-Pearson]: 83.2%–100%). This result should be interpreted with caution given the small sample size and the lack of independent adjudication.
Conclusion: These preliminary findings suggest that structured prompt engineering may meaningfully improve LLM-assisted diagnostic reasoning. The R-DA protocol warrants further investigation through prospective, multi-center trials with blinded adjudication. This study does not support claims of specialistlevel performance, but provides a hypothesis-generating foundation for future validation work

Key words: Gemini, R-DA, structured prompting protocol, feasibility study.

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How to Cite this Article

Pubmed Style

Kawssan A, Bazzal AA, Abdelhadi A, Hamdar H. Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series . J Med Res Rev. 2026; 5(3): 116-124. doi:10.5455/JMRR.20251219010830

Web Style

Kawssan A, Bazzal AA, Abdelhadi A, Hamdar H. Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series . https://www.wisdomgale.com/jmrr/?mno=303792 [Access: July 11, 2026]. doi:10.5455/JMRR.20251219010830

AMA (American Medical Association) Style

Kawssan A, Bazzal AA, Abdelhadi A, Hamdar H. Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series . J Med Res Rev. 2026; 5(3): 116-124. doi:10.5455/JMRR.20251219010830

Vancouver/ICMJE Style

Kawssan A, Bazzal AA, Abdelhadi A, Hamdar H. Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series . J Med Res Rev. (2026), [cited July 11, 2026]; 5(3): 116-124. doi:10.5455/JMRR.20251219010830

Harvard Style

Kawssan, A., Bazzal, . A. A., Abdelhadi, . A. & Hamdar, . H. (2026) Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series . J Med Res Rev, 5 (3), 116-124. doi:10.5455/JMRR.20251219010830

Turabian Style

Kawssan, Aya, Abbas Al Bazzal, Aktham Abdelhadi, and Hiba Hamdar. 2026. Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series . Journal of Medical Research and Reviews, 5 (3), 116-124. doi:10.5455/JMRR.20251219010830

Chicago Style

Kawssan, Aya, Abbas Al Bazzal, Aktham Abdelhadi, and Hiba Hamdar. "Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series ." Journal of Medical Research and Reviews 5 (2026), 116-124. doi:10.5455/JMRR.20251219010830

MLA (The Modern Language Association) Style

Kawssan, Aya, Abbas Al Bazzal, Aktham Abdelhadi, and Hiba Hamdar. "Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series ." Journal of Medical Research and Reviews 5.3 (2026), 116-124. Print. doi:10.5455/JMRR.20251219010830

APA (American Psychological Association) Style

Kawssan, A., Bazzal, . A. A., Abdelhadi, . A. & Hamdar, . H. (2026) Clinical Manuscript: Feasibility and Proof-of-Concept of the Rapid Dx Analyzer Structured Prompting Protocol: Achieving High Diagnostic Concordance in a Retrospective Case Series . Journal of Medical Research and Reviews, 5 (3), 116-124. doi:10.5455/JMRR.20251219010830