Abstract
Langerhans cell histiocytosis (LCH) is an uncommon disease spectrum that occurs mostly in children and young adults and is characterized by the proliferation of Langerhans cells in the affected organ or tissue. Due to its nonspecific clinical findings and symptoms and variable radiological appearances, sometimes problems can be experienced in the diagnosis of Langerhans cell histiocytosis. Histopathological results are still the basis for the diagnosis of LCH rather than imaging techniques. However, MRI not only characterizes the lesion but also plays an important role in the follow-up of the lesion and in the evaluation of the response to any treatment. In this case, the radiological and histopathological features of eosinophilic granuloma are discussed together with the follow-up MRI findings of a five-year-old girl who was diagnosed with eosinophilic granuloma (EG) with spontaneous regression findings in her clinico-radiological follow-up. The rarity of spontaneous regression of eosinophilic granuloma and the lack of a definitive histopathology make this case unique.