Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies

Ayatullah Darwish; Farah Bakier; Ali El Banbi; Andreas Kakarougkas

doi:10.5455/JCRR.20240916121830

2025, Vol: 2, Issue: 1

2 / 1Current Issue Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Review Article
Online Published: 07 Feb 2025

J Cancer Res Rev. 2025; 2(1): 19-31

doi: 10.5455/JCRR.20240916121830

Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies

Ayatullah Darwish, Farah Bakier, Ali El Banbi, Andreas Kakarougkas.

Abstract
Multiple myeloma is a cancer in the blood that develops in the plasma cells of bone marrow. Classic treatments for this cancer include chemotherapy and a newly found therapy known as CAR-T therapy that has already been found to have a significant effect on cancer patients who have been newly diagnosed with multiple myeloma. As this is a new yet commonly researched and observed therapy, newer drugs have begun to emerge through the biosynthetic mechanisms of molecular and cell modification in the efficiency and effectiveness of recent drugs including Daratumumab, Elotuzumab, and Isatuximab, that assist in patients that have relapsed or have been re-diagnosed with multiple myeloma after prior treatments such as chemotherapy. These drugs incorporate the utilization of monoclonal antibodies and their ability to defend the immune system and fight off foreign antigens. Alongside these emerging treatments, is the new specialization of immunotherapy and immunocytokines. These proteins have been found to successfully fight off tumor cells by communicating with the immune system, and have shown assuring results. The following review aims to focus on these newly discovered antibody targets including CD38 (Daratumumab and Isatuximab), and SLAM7 (Elotuzumab) for the treatment of multiple myeloma in clinical research.

Key words: Multiple Myeloma, Genetic Engineering, Monoclonal Antibodies, CAR-T Therapy, Immunocytokines, Daratumumab, Elotuzumab, Isatuximab.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Ayatullah Darwish Articles by Farah Bakier Articles by Ali El Banbi Articles by Andreas Kakarougkas
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Darwish A, Bakier F, Banbi AE, Kakarougkas A. Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies. J Cancer Res Rev. Online First: 07 Feb, 2025. doi:10.5455/JCRR.20240916121830

Web Style

Darwish A, Bakier F, Banbi AE, Kakarougkas A. Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies. https://www.wisdomgale.com/jcrr/?mno=220763 [Access: February 08, 2025]. doi:10.5455/JCRR.20240916121830

AMA (American Medical Association) Style

Darwish A, Bakier F, Banbi AE, Kakarougkas A. Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies. J Cancer Res Rev. Online First: 07 Feb, 2025. doi:10.5455/JCRR.20240916121830

Vancouver/ICMJE Style

Darwish A, Bakier F, Banbi AE, Kakarougkas A. Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies. J Cancer Res Rev, [cited February 08, 2025]; Online First: 07 Feb, 2025. doi:10.5455/JCRR.20240916121830

Harvard Style

Darwish, A., Bakier, . F., Banbi, . A. E. & Kakarougkas, . A. (2025) Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies. J Cancer Res Rev, Online First: 07 Feb, 2025. doi:10.5455/JCRR.20240916121830

Turabian Style

Darwish, Ayatullah, Farah Bakier, Ali El Banbi, and Andreas Kakarougkas. 2025. Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies. Journal of Cancer Research and Reviews, Online First: 07 Feb, 2025. doi:10.5455/JCRR.20240916121830

Chicago Style

Darwish, Ayatullah, Farah Bakier, Ali El Banbi, and Andreas Kakarougkas. "Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies." Journal of Cancer Research and Reviews Online First: 07 Feb, 2025. doi:10.5455/JCRR.20240916121830

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Darwish, A., Bakier, . F., Banbi, . A. E. & Kakarougkas, . A. (2025) Molecular Biology of Multiple Myeloma (MM): Treatment Approaches using Monoclonal Antibodies. Journal of Cancer Research and Reviews, Online First: 07 Feb, 2025. doi:10.5455/JCRR.20240916121830

Author Login Reviewer Login About Publisher Open Access Policy Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Privacy Policy Corrections, Retractions & Expressions of Concern Self-Archiving Policies Digital Archiving & Preservation Policies Terms of Use License Information Copyright Information

About Journal of Cancer Research and Reviews

Journal of Cancer Research and Reviews is an international journal that considers full-length articles in the broad area of basic, clinical and translatio ... Read more.

For best results, please use Internet Explorer or Google Chrome.

Contact Information

Your comments are very important to us

We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below.

Emails:

info@wisdomgale.com
editorinchief@ejmanager.com

Office Address:
WisdomGale Publishing
14 Rue de Grand-Bigard,
1082 Brussels
Belgium

We will respond within 48 to 72 hours.

Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.

About Journal of Cancer Research and Reviews

Contact Information

Your comments are very important to us

How to cite this article