Prognostic value of thrombomodulin molecule in COVID-19 patients

Kezban Ozmen Süner; Havva Kocayiğit; Kubilay Işsever; Betül Tuncer; Erdem Cokluk; Hande Toptan; Selcuk Yaylacı; Oğuz Karabay

doi:10.5455/EJMID.20240424010154

Original Article
Online Published: 23 May 2024

Eu J Microbiol Infect Dis. 2024; 1(1): 30-36

doi: 10.5455/EJMID.20240424010154

Prognostic value of thrombomodulin molecule in COVID-19 patients

Kezban Ozmen Süner, Havva Kocayiğit, Kubilay Işsever, Betül Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, Oğuz Karabay.

Abstract
Background:The purpose of this study is to evaluate serum thrombomodulin(TM) levels in coronavirus disease 2019(COVID-19) patients and to investigate whether TM predicts the severity of COVID-19 and coagulopathy .
Materials and methods:This study was conducted on 87 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia.The patients were divided into two groups as intensive care unit(ICU) patients and non-ICU patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the TM and other laboratory parameters of the patients.
Results:Of 87 patients with COVID-19, 40(45%) were ICU patients and 47(55%) were non-ICU patients. 40(45%) of the patients were men.TM median value(IQR) was 1.22ng/mL (0.9–2.2) in all patients, 1.2ng/mL(0.8–2.3) in non-ICU patients and 1.3ng/mL (1.0–2.21) in ICU patients (p=0.485).As a receiver operating characteristic curve analysis the cut-off value of TM for predicting mortality in patients was 1.27 with 60% sensitivity and 54% specificity (AUC: 0.550, 95% CI: 0.384-0.716, P= 0.602).Also, we found significant cut-off values with respect to troponin, D-dimer, CRP, fibrinogen, procalcitonin, LDH, and ferritin(p< 0.05).
Conclusion:This study found no significant difference between TM levels in ICU versus non-ICU groups.We further showed that there is no relation between TM levels and mortality.

Key words: prognostic value, thrombomodulin molecule, COVID-19, endotheliitis

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How to Cite this Article

Pubmed Style

Suner KO, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, Yaylacı S, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis. 2024; 1(1): 30-36. doi:10.5455/EJMID.20240424010154

Web Style

Suner KO, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, Yaylacı S, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. https://www.wisdomgale.com/ejmid/?mno=198961 [Access: June 06, 2026]. doi:10.5455/EJMID.20240424010154

AMA (American Medical Association) Style

Suner KO, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, Yaylacı S, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis. 2024; 1(1): 30-36. doi:10.5455/EJMID.20240424010154

Vancouver/ICMJE Style

Suner KO, Kocayiğit H, Işsever K, Tuncer B, Cokluk E, Toptan H, Yaylacı S, Karabay O. Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis. (2024), [cited June 06, 2026]; 1(1): 30-36. doi:10.5455/EJMID.20240424010154

Harvard Style

Suner, K. O., Kocayiğit, . H., Işsever, . K., Tuncer, . B., Cokluk, . E., Toptan, . H., Yaylacı, . S. & Karabay, . O. (2024) Prognostic value of thrombomodulin molecule in COVID-19 patients. Eu J Microbiol Infect Dis, 1 (1), 30-36. doi:10.5455/EJMID.20240424010154

Turabian Style

Suner, Kezban Ozmen, Havva Kocayiğit, Kubilay Işsever, Betul Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, and Oğuz Karabay. 2024. Prognostic value of thrombomodulin molecule in COVID-19 patients. European Journal of Microbiology and Infectious Diseases, 1 (1), 30-36. doi:10.5455/EJMID.20240424010154

Chicago Style

Suner, Kezban Ozmen, Havva Kocayiğit, Kubilay Işsever, Betul Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, and Oğuz Karabay. "Prognostic value of thrombomodulin molecule in COVID-19 patients." European Journal of Microbiology and Infectious Diseases 1 (2024), 30-36. doi:10.5455/EJMID.20240424010154

MLA (The Modern Language Association) Style

Suner, Kezban Ozmen, Havva Kocayiğit, Kubilay Işsever, Betul Tuncer, Erdem Cokluk, Hande Toptan, Selcuk Yaylacı, and Oğuz Karabay. "Prognostic value of thrombomodulin molecule in COVID-19 patients." European Journal of Microbiology and Infectious Diseases 1.1 (2024), 30-36. Print. doi:10.5455/EJMID.20240424010154

APA (American Psychological Association) Style

Suner, K. O., Kocayiğit, . H., Işsever, . K., Tuncer, . B., Cokluk, . E., Toptan, . H., Yaylacı, . S. & Karabay, . O. (2024) Prognostic value of thrombomodulin molecule in COVID-19 patients. European Journal of Microbiology and Infectious Diseases, 1 (1), 30-36. doi:10.5455/EJMID.20240424010154