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Original Article
Online Published: 31 Aug 2024
 


Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus

Hassan Abdulsalam, Joseph John Gadzama, Mohammed Adam Chiroma, Sani Dahiru, Halima Idrisa Gambo, Jamila Abdulhamid Atata, Sohnap James Sambo, Sani Adamu.


Abstract
Aim: To evaluate serum hepatic changes induced by lead acetate (PbA) and the ameliorative effect of aqueous extract of Adansonia digitata fruit pulp (AEADFP) in Clarias gariepinus.
Methods: A total of 120 Clarias gariepinus (185 ± 5 g) were assigned randomly into 6 groups (A, B, C, D, E and F) of n=20. Group A was administered borehole water for 35 days; Group B, C, D, E and F were administered PbA for 14 days and subsequently borehole water, 195 mg/L of AEADFP, 390 mg/L of AEADFP, 585 mg/L of AEADFP and 15 mg/L of dimercaptosuccinic acid (DMSA), respectively, for 21 days. Four fish per group were randomly selected on weekly basis for serum biochemical analysis of hepatic function markers.
Results: There was significant (p<0.05) elevation in alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin and total cholesterol levels in the PbA-induced groups B, C, D, E and F, at week 2 post-induction. Contrarily, total protein and albumin decrease in group B, C, D, E and F, to the lowest mean values of 1.1 ± 0.1 g/dL and 0.7 ± 0.2 g/dL, respectively at week 2 post-induction. However, treatment of PbA-induced group C, D, E and F with AEADFP and DMSA, respectively, significantly ameliorated the negative effects of PbA when compared with the PbA-induced but untreated group.
Conclusion: The findings in this study suggest that Adansonia digitata fruit extract has a mitigating potential against PbA-induced hepatotoxicity by ameliorating the upsurge and downturn of liver function parameters. Hence, Adansonia digitata fruits can serve as a natural plant agent in the treatment of lead-induced hepatotoxicity in Clarias gariepinus.

Key words: Adansonia digitata, Clarias gariepinus, Hepatic function parameters, Lead acetate,


 
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How to Cite this Article
Pubmed Style

Abdulsalam H, Gadzama JJ, Chiroma MA, Dahiru S, Gambo HI, Atata JA, Sambo SJ, Adamu S, . Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus. J Res Complement Med. 2024; 1(2): 92-102. doi:10.5455/JRCM.20240818120241

Web Style

Abdulsalam H, Gadzama JJ, Chiroma MA, Dahiru S, Gambo HI, Atata JA, Sambo SJ, Adamu S, . Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus. https://www.wisdomgale.com/jrcm/?mno=216090 [Access: September 13, 2024]. doi:10.5455/JRCM.20240818120241

AMA (American Medical Association) Style

Abdulsalam H, Gadzama JJ, Chiroma MA, Dahiru S, Gambo HI, Atata JA, Sambo SJ, Adamu S, . Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus. J Res Complement Med. 2024; 1(2): 92-102. doi:10.5455/JRCM.20240818120241


Vancouver/ICMJE Style

Abdulsalam H, Gadzama JJ, Chiroma MA, Dahiru S, Gambo HI, Atata JA, Sambo SJ, Adamu S, . Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus. J Res Complement Med. (2024), [cited September 13, 2024]; 1(2): 92-102. doi:10.5455/JRCM.20240818120241


Harvard Style

Abdulsalam, H., Gadzama, J. J., Chiroma, M. A., Dahiru, S., Gambo, H. I., Atata, J. A., Sambo, S. J., Adamu, S. & (2024) Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus. J Res Complement Med, 1 (2), 92-102. doi:10.5455/JRCM.20240818120241


Turabian Style

Abdulsalam, Hassan, Joseph John Gadzama, Mohammed Adam Chiroma, Sani Dahiru, Halima Idrisa Gambo, Jamila Abdulhamid Atata, Sohnap James Sambo, Sani Adamu, and . 2024. Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus. Journal of Research in Complementary Medicine, 1 (2), 92-102. doi:10.5455/JRCM.20240818120241


Chicago Style

Abdulsalam, Hassan, Joseph John Gadzama, Mohammed Adam Chiroma, Sani Dahiru, Halima Idrisa Gambo, Jamila Abdulhamid Atata, Sohnap James Sambo, Sani Adamu, and . "Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus." Journal of Research in Complementary Medicine 1 (2024), 92-102. doi:10.5455/JRCM.20240818120241


MLA (The Modern Language Association) Style

Abdulsalam, Hassan, Joseph John Gadzama, Mohammed Adam Chiroma, Sani Dahiru, Halima Idrisa Gambo, Jamila Abdulhamid Atata, Sohnap James Sambo, Sani Adamu, and . "Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus." Journal of Research in Complementary Medicine 1.2 (2024), 92-102. Print. doi:10.5455/JRCM.20240818120241


APA (American Psychological Association) Style

Abdulsalam, H., Gadzama, J. J., Chiroma, M. A., Dahiru, S., Gambo, H. I., Atata, J. A., Sambo, S. J., Adamu, S. & (2024) Lead Acetate-Induced Hepatotoxicity and the ameliorative effect of Aqueous Extract of Adansonia digitata Fruit Pulp in Clarias gariepinus. Journal of Research in Complementary Medicine, 1 (2), 92-102. doi:10.5455/JRCM.20240818120241


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